Published Date: 2001-12-13 23:50:00
Subject: PRO/EDR> Malaria, mefloquine resistant - Tanzania
Archive Number: 20011213.3015
MALARIA, MEFLOQUINE RESISTANT - TANZANIA
********************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>
See Also
Malaria, chloroquine resistant, fatal - USA ex Africa 20010728.1475Malaria, chloroquine resistant - Burundi 20010628.1233
Malaria, chloroquine resistant - Tanzania 20010514.0935
1999
----
Malaria, quinine resistance - Kenya: RFI 19990528.0903
Malaria, quinine resistance - Kenya (02) 19990604.0933
1997
----
Malaria, mefloquine prophylaxis 19970320.0585
Malaria, mefloquine prophylaxis (02) 19970321.0596
Date: Wed, 12 Dec 2001
From: Tomas Jelinek <jelinek@lrz.uni-muenchen.de>
Source: TropNetEurop [edited
Mefloquine-resistant falciparum malaria from Tanzania
----------------------------------------------------
One month ago, this patient who was seen at our outpatient clinic: F,
44y, travelled to Tanzania for 3 weeks (tourism). Fever, headache,
malaise, myalgia started 3 weeks after return and the patient was treated
with treatment with doxycycline through family doctor has no effect.
The patient was diagnosed with _P. falciparum_ malaria with a very
low parasitaemia (only very few trophozoites in thick film). The patient
was treated with Riamet, and showed a good response.
Analysis of blood concentrations of mefloquine at time of admission
showed 1400 ng/ml (B. Betschart, Switzerland) 2 days after the last
intake of mefloquine. This level is consistent with protective blood
concentrations. Thus, our patient managed to acquire a truly
mefloquine-resistant Pf strain.
--
Ole Wichmann & Tomas Jelinek
University of Munich
Department of Infectious Diseases and Tropical Medicine
Leopoldstr. 5, 80802 Munich, Germany
Tel: (x49)-89-2180 3830 / 3517
Fax: (x49)-89-33 61 12
<jelinek@lrz.uni-muenchen.de>
URL:
[Reports of _P.falciparum_ resistant to mefloquine are rare from
Africa. This case is well documented, and there is little doubt that the
patient had a truly mefloquin-resistant _P.falciparum_ infection.
However, mefloquine should still be regarded as an efficient anti-
malaria drug until further data become available, but patients must be
warned that symptoms -- despite treatment or prophylaxis with
mefloquine -- should be regarded as malaria. - Mod.EP
.........................ep/pg/jw
*##########################################################*
ProMED-mail makes every effort to verify the reports that
are posted, but the accuracy and completeness of the
information, and of any statements or opinions based
thereon, are not guaranteed. The reader assumes all risks in
using information posted or archived by ProMED-mail. ISID
and its associated service providers shall not be held
responsible for errors or omissions or held liable for any
damages incurred as a result of use or reliance upon posted
or archived material.
************************************************************
Visit ProMED-mail's web site at <http://www.promedmail.org>.
Send all items for posting to: promed@promedmail.org
(NOT to an individual moderator). If you do not give your
full name and affiliation, it may not be posted. Send
commands to subscribe/unsubscribe, get archives, help,
etc. to: majordomo@promedmail.org. For assistance from a
human being send mail to: owner-majordomo@promedmail.org.
############################################################
############################################################