Published Date: 2002-01-26 23:50:00
Subject: PRO/AH> Chronic wasting disease, cervids - USA (Nebraska) (02)
Archive Number: 20020126.3402

CHRONIC WASTING DISEASE, CERVIDS - USA (NEBRASKA) (02)
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See Also

Chronic wasting disease, cervids - USA (Nebraska) 20020124.3374
Chronic wasting disease, cervids - USA (Kansas) 20020101.3145
1991
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Chronic wasting disease, cervids - USA (Nebraska) 20011228.3123
Date: 25 Jan 2002
From: Gayle Knapp <gayle@mail.mtwest.net>

It is curious that the distribution of Transmissible Spongiform
Encephalopathy (TSE) in Nebraska (NE) deer is in proximity to only one
of 2 areas of TSE occurrence. It raises the question posed below:
We understand that the available evidence from sheep, deer, and elk
suggest at least 2 separate factors: genetics and some type of contact
transmission (possibly even a low-level sexually transmitted
disease-type prion 'infectivity') are necessary to explain the
occurrence of TSE in these wild populations.
Scrapie in sheep clearly coincides with certain well-defined genetic
polymorphisms in sheep PrP. Why is there no TSE (so far) in the wild
herds in Sioux County? Is it lack of some proximity/direct contact
with captive herds -- or genetic differences between captives and
wild, and genetic similarities among NE, Colorado (CO) and Wyoming
(WY) wild herds? Given all the time and expense that has already been
invested by CO, WY, and NE in these investigations, we hope they're
also checking the genotype of PrP in all the affected animals.
--
Gayle Knapp
Bruce Copeland
CyberSym Technologies, Providence, UT
<gayle@mail.mtwest.net>
............................tg/pg/jw

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